Regimens for the Eradication of Helicobacter Pylori

Various regimens ranging from 3 days to 8 weeks or more have been evaluated in H pylori eradication, and there seems to be no consensus on the most appropriate continuance.
A meta-analysis of 13 studies compared 7-day, 10-day, and 14-day period of time using a PPI, clarithromycin, and either amoxicillin or metronidazole. Fourteen-day therapies were significantly punter (7% to 9% shift in cure rates) as compared with 7-day therapies (cure rates of 75% to 80%).
Comparisons of 7-day vs 10-day and 10-day vs 14-day regimens showed a nonsignificant discernment toward goodness cure rates with longer therapies.
On the other hand, a meta-analysis of 66 studies evaluating 132 different medicament combinations did not reveal any disagreement in eradication rates with gaze to length of communicating.

Equally high efficacy of 4-day, 7-day, and 10-day base hit therapies was shown by a recent double-blind examination in 76 patients with H pylori-associated ulcers, whereas lower cure rates were seen in a 7-day regimen as compared with a 14-day regimen.

Another recent knowledge domain in patients with endoscopically proven H pylori-positive duodenal ulcers showed that 3-day therapy with RBC plus amoxicillin plus clarithromycin plus metronidazole achieved an eradication rate of 95%.
Another “quadruple” therapy regimen (omeprazole, amoxicillin, tinidazole, and bismuth subcitrate) did not achieve a cure rate of 90%. On the other hand, 5-day quadruplet regimen (rabeprazole, amoxicillin, clarithromycin, and metronidazole) was Lake Superior to 7-day three-base hit therapy (rabeprazole, amoxicillin, and clarithromycin), with eradication rates of 93% (95% CI = 84% to 97%) and 81% (95% CI = 71% to 89%; P < .05), respectively. Short-term quadruplet therapies have also been shown to be effective, safe, and easy to follow in other studies. More meta-analyses are perhaps required to clarify the position of short-term regimens as well as to optimize the period of tending.
This is a part of article Regimens for the Eradication of Helicobacter Pylori Taken from "Generic Aciphex (Rabeprazole) Review" Information Blog