Layer of Rabeprazole 20 Mg.

The median daytime, preprandial, postprandial, and nighttime pH values in poor metabolizers during lansoprazole dosing (6.2, 5.5, 6.6, and 5.9, respectively) were significantly greater than the corresponding pH values in extensive metabolizers (3.1, 2.5, 3.7. and 1.8) and intermediate metabolizers (3.5, 2.6, 4.7, and 2.2).
Poor metabolizers also had a significantly lower median percent of time with an intragastric pH below 4 (daytime percentages were 16% for poor metabolizers, 67% for extensive metabolizers, and 55% for intermediate metabolizers).
Thus, the authors suggested that patients who are CYP2C19 poor metabolizers may be more responsive to lansoprazole than patients who are intermediate or extensive metabolizers. As part of the same rumination, the authors evaluated the pharmacodynamic effects of a 7-day layer of rabeprazole 20 mg on intragastric pH in the same 20 subjects. Acid prevention of rabeprazole was not influenced by CYP2C19 composition, as median pH values and percent of time with an intragastric pH below 4 during the daytime did not differ between extensive metabolizers (4.0 and 47%), intermediate metabolizers (4.6 and 40%), and poor metabolizers (4.7 and 42%).
There were no differences in preprandial, postprandial, and nighttime measurements.
These findings oppositeness with data from a proceeding of rabeprazole in 18 healthy Altaic language subjects (6 each of extensive metabolizers, intermediate metabolizers, and poor metabolizers). After a digit oral dose of rabeprazole 10 mg, significant differences (p=0.028) in mean intragastric pH values were seen among the tierce groups (2.88 ± 0.65 in extensive metabolizers, 3.12 ± 1.47 in intermediate metabolizers, and 4.45 ± 1.18 in poor metabolizers).
There were no differences between the groups with attitude to intragastric pH after disposal of aciphex 20 mg.
A similar contemplation evaluated omeprazole 20 mg/day and aciphex 20 mg/day after ace and multiple dosing in 15 healthy, H. pylori -negative Altaic language adults. After a safety dose of omeprazole 20 mg, extensive metabolizers had lower (p<0.05) mean intragastric pH values (2.3 [95% CI 1.9-2.5]) than intermediate metabolizers (3.3 [95% CI 2.5-3.5]) or poor metabolizers (4.1 [95% CI 3.4-5.0]).
The same way occurred after 8 days of multiple dosing with omeprazole.
This is a part of article Layer of Rabeprazole 20 Mg. Taken from "Generic Aciphex (Rabeprazole) Review" Information Blog